Radioimmunotherapy is a new form of therapy that uses monoclonal antibodies in the treatment of patients with non-Hodgkin’s lymphoma (NHL). In this form of therapy, the monoclonal antibodies are labelled with a radionuclide. The monoclonal antibodies carry the radionuclide highly selectively to the malignant cells. The beta radiation the radionuclide emits then destroys the malignant cell the antibody has bound to, and malignant cells in the vicinity
❰❰ PATIENTS INSTRUCTIONS
|• This procedure requires exposure to radioactive material.|
|• If there is a possibility that you are pregnant, please inform the Nuclear Medicine staff.|
|• If you are breast-feeding, please inform the Nuclear Medicine staff.|
|• Please inform the Nuclear Medicine staff about previous therapies (chemotherapy, radiation therapy.. etc.)|
|• Bone marrow biopsy from the iliac crest is a pre-therapeutic requirement.|
|• This procedure may require an additional nuclear medicine scan prior to therapy.|
|• Bring a list of your medications with you.|
|• Lab tests are required within 1 week before therapy:|
|o Blood profile.|
|o Prothrombin time (INR).|
|o Serum Creatinine.|
|• Fasting is not required for this procedure.|
|• There are NO special precautions after the therapy dose.|
❰❰ RADIATION SAFETY
Nuclear medicine diagnostic procedures are safe except for pregnant ladies, unless it is requested by the physician for exceptional cases. However, the procedure better to be discussed with the doctor to know the desired benefits of the test and the alternative procedures, or you can ask the the nuclear medicine specialist about the procedure.
No, you shouldn’t because nuclear medicine scans use high-energy radioisotopes, the radiation passes directly from the other person without interacting with tissues. In contrast, wearing a lead apron slows down the radiation beam, which allows it to deposit its energy in the body and interact with tissues.
The risks from diagnostic doses are usually small compared to other lifetime risks to which the patient is exposed to and the amount of radiation dose in most diagnostic procedures is less than an x-ray, CT scan, or fluoroscopy.
When the body is exposed to radiation, tissue damage may occur, which in turn may damage DNA or chromosomes, increasing the risk of genetic mutations. When a fetus is exposed to radiation doses, it may cause abnormalities in an organ or irreparable damage and if the radiation dose is too high, it may cause the death of the fetus.
The radioactive dose used in diagnostic procedures in nuclear medicine is very low, unlike radiation treatments in which the amount of radioactive dose is high and this gives the desired effect on the tissues or organs when radiotherapy. That is why the patient must undergo a pregnancy test in the event of suspicion or if the pregnancy is uncertain before starting the therapeutic doses.
In diagnostic procedures the radioactivity is very low. However, the patient may be asked to maintain a distance of approximately one meter between him and his family members for a period of time given by the nuclear medicine specialist to protect them from exposure to radiation.
One the other hand, in therapeutic procedures, the patients may present some slight risk to their family members if they do not follow the INSTRUCTIONS ON RADIATION SAFETY given to them by the nuclear medicine specialist.
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